US FDA puts on hold Rein Therapeutics' lung disease drug trial

- 6/12/2025

</head><body><p>(Reuters) -Rein Therapeutics has paused patient enrollment and dosing in a mid-stage trial of its lung disease drug in the U.S. after the Food and Drug Administration placed a clinical hold, the drug developer said on Thursday. </p><p>Shares of the company fell nearly 10% after the bell. </p><p>The company was testing a drug named LTI-03 to treat patients with idiopathic pulmonary fibrosis (IPF). The disease causes scarring of the lungs that makes it harder for them to work properly.</p><p>Rein said in a filing that it is actively working with the FDA to remove the clinical hold.</p><p>The FDA and Rein did not immediately respond to Reuters' requests for comment on why the hold was placed. </p><p>The drug was well-tolerated and safe in an early-stage study in patients with IPF, the company said in the filing. No drug-related serious adverse events have been reported in any studies treating patients with LTI-03, it added.</p><p>Rein continues to study the drug and enroll patients in Australia and Europe. </p><p> (Reporting by Siddhi Mahatole in Bengaluru; Editing by Sahal Muhammed)</p></body></html></p> <div id="news-wrapper"> <div class="thumbnail additional-resources client-content-image-box"> <div class="box-image" style="background-image: url(/images/home/news.jpg);"></div> <div class="caption"> <h3>Nationwide News</h3> <div> <p><a href='/aging/news-archive.aspx'>News Archive</a></p> </div> </div> </div> </div> </div> </div> </div> </section> </div>  <footer class="footer">  <div class="clearfix footerInfo"> <div class="container"> <div class="row"> <div class="col-sm-7 col-xs-12"> <div class="footerText"> <a href="http://www.trilogyir.com/" target="_blank" class="footerLogo"><img src="/images/Noc-Logo-white.png" alt="Footer Logo" style="width: 200px;"></a> <div class="genericContent" id="landingPageText"> <p>The Network of Care is a comprehensive, Internet-based community resource for seniors and persons with disabilities, as well as their caregivers and service providers.</p> </div> <h3 id="lblTechAssistance" style="color: #fff; 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US FDA puts on hold Rein Therapeutics' lung disease drug trial